Known conditions.Unanswered questions.
Sourced information on POTS, dysautonomia, hypermobility and MCAS, for patients and the people around them. Every sentence shows how solid it is and where it comes from.
Select a condition to see what links it to the others.
- Dysautonomia Established. POTS is one form of orthostatic intolerance, a family of autonomic nervous system disorders.
- Hypermobility Debated. An association found in several studies, mostly in specialist centres. How large it is remains debated.
- MCAS Hypothesis. Often suggested. A 2025 review found no study confirming it with strict criteria.
- POTS Established. POTS is one form of orthostatic intolerance, a family of autonomic nervous system disorders.
- Hypermobility Debated. Orthostatic intolerance appears more common in hypermobile people. The data remain limited.
- MCAS Hypothesis. Proposed and little studied. No solid data in the sources read so far.
- POTS Debated. An association found in several studies, mostly in specialist centres. How large it is remains debated.
- Dysautonomia Debated. Orthostatic intolerance appears more common in hypermobile people. The data remain limited.
- MCAS Hypothesis. Same finding: the POTS, EDS, MCAS “triad” is not confirmed by the studies available.
- POTS Hypothesis. Often suggested. A 2025 review found no study confirming it with strict criteria.
- Hypermobility Hypothesis. Same finding: the POTS, EDS, MCAS “triad” is not confirmed by the studies available.
- Dysautonomia Hypothesis. Proposed and little studied. No solid data in the sources read so far.
One line, one level of evidence
- Established
- Debated
- Hypothesis
- Unknown
Four conditions
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